Subcutaneous DMPA (Sayana Press):
Expanding contraceptive access and options
About the product
Subcutaneous DMPA*(DMPA-SC) is a new, lower-dose, easy-to-use injectable contraceptive that is administered every three months under the skin rather than into the muscle. Sayana® Press, the subcutaneous DMPA product available to Family Planning 2020 (FP2020) countries, is manufactured by Pfizer Inc. and combines the drug and needle in the prefilled BD Uniject™ injection system. The product’s user-friendly design means that any trained person can administer it, including community health workers, pharmacists, and even women themselves through self-injection.
Self-injection with subcutaneous DMPA
Self-injection of Pfizer’s subcutaneous DMPA product, Sayana Press was officially approved by the United Kingdom’s lead stringent regulatory authority in 2015, and has been recommended by the World Health Organization in contexts where women have information, training, and support. PATH’s research to determine the feasibility and acceptability of self-injection in Senegal and Uganda suggest that most women are able to self-inject competently three months after one-on-one training. These studies, co-led by the Senegal and Uganda ministries of health, led directly to government decisions to pilot self-injection outside of a research setting in both countries.
Two additional studies are ongoing in Senegal and Uganda to assess whether women who self-inject continue using injectable contraception longer than women who receive intramuscular DMPA from a provider at a clinic, and to assess the cost-effectiveness of each approach.
In 2016, PATH also coordinated the first offer of contraceptive self-injection outside a research setting in Mubende district, Uganda. PATH worked with the Ministry of Health and district leadership to teach over 100 health providers at government facilities to train clients to self-inject. Now, under a project designed to identify and share self-injection best practices, PATH and the Uganda Ministry of Health are applying evidence from self-injection studies to design and deliver programs at facilities in the public sector, through community-based distribution, and in the private sector.
Product introduction: Making injections available from new providers
Subcutaneous DMPA has been available from providers in Senegal, Uganda, Burkina Faso, and Niger since 2014 under a country-led introduction initiative coordinated by PATH. These introductions have helped to make injectable contraception available in remote locations, closer to where women live. Between July 2014 and June 2016, nearly 500,000 doses of Sayana Press were administered by family planning providers in the four countries. Now, all four countries, in additional to several other countries worldwide, are moving forward with scale-up of provider-administered subcutaneous DMPA into their national family planning programs.
To understand the potential impact of subcutaneous DMPA administered by providers, PATH and partners are also conducting studies on the effectiveness and cost-effectiveness of subcutaneous DMPA administered by clinic-based (Burkina Faso) and community-based (Uganda) health providers; results are forthcoming in 2017.
Pricing and regulatory approval of Sayana Press
Under a pricing agreement negotiated by Pfizer Inc., the Bill & Melinda Gates Foundation, and the Children’s Investment Fund Foundation (CIFF) in 2017, qualified purchasers in FP2020 countries can obtain Sayana Press for US$0.85 per dose. For more information, please email FPoptions@path.org.
Sayana Press has regulatory approval in the European Union and more than 25 countries around the world.† The formulation of depot medroxyprogesterone acetate (DMPA) used in Sayana Press is also approved in the United States.
Key fact sheets
- Advocacy pack for subcutaneous DMPA
- Subcutaneous DMPA Access Collaborative
- Self-Injection Feasibility and Acceptability
- Self-Injection Best Practices Project: Uganda
- Monitoring Sayana Press Pilot Introduction
- Frequently Asked Questions About Sayana Press
- Sayana Press Clinical Brief
- Dossier de plaidoyer du DMPA Sous-Cutané
- Suivi de L’introduction Pilote de Sayana Press
- Questions Fréquentes Concernant Sayana Press
- Sayana Press Dossier Clinique
- April 2018 newsletter
- January 2018 newsletter
- October 2017 newsletter
- July 2017 newsletter
- March 2017 newsletter
- November 2016 pilot introduction newsletter
- July 2016 self-injection newsletter
- April 2016 pilot introduction newsletter
- January 2016 self-injection newsletter
- October 2015 pilot introduction newsletter
- July 2015 self-injection newsletter
- April 2015 pilot introduction newsletter
- Janvier 2018 bulletin
- Octobre 2017 bulletin
- Juillet 2017 bulletin
- Mars 2017 bulletin
- Novembre 2016 bulletin introduction pilote
- Juillet 2016 bulletin auto-administration
- Avril 2016 bulletin introduction pilote
- Janvier 2016 bulletin auto-administration
- Octobre 2015 bulletin introduction pilote
- Julliet 2015 bulletin auto-administration
- Avril 2015 bulletin introduction pilote
PATH blog posts and features
- Sayana Press: a contraceptive within reach
- Power in her hands: the story of Sayana Press (multimedia)
- How an innovative contraceptive changed these women’s lives (slideshow)
- Giving Ugandan women a new contraceptive option (video)
- Empowering women who want to “stick” with contraception (2018)
- A condom for women, a diaphragm, and an all-in-one injectable contraceptive (2015)
- An implementer’s perspective on family planning as a human right (2015)
- Empowering women one page at a time (2015)
- A novel contraceptive makes life easier in Uganda and beyond (2014)
- How the right contraceptive can change a woman’s life (2014)
- Putting family planning within reach (2013)
- New study results from Uganda strengthen the case for contraceptive self-injection (2018)
- PATH welcomes $10.5 million grant to expand contraceptive choice and access (2017)
- Groundbreaking study: self-injection of contraceptive is feasible, acceptable in Uganda (2016)
- PATH welcomes groundbreaking regulatory approval for contraceptive self-injection (2015)
- PATH welcomes news that millions more women can access Sayana Press (2014)
- Injectable contraceptive launched in Burkina Faso to expand choice and address unmet need (2014)
For more information, please email FPoptions@path.org.
Sayana Press and Depo-Provera are registered trademarks of Pfizer Inc. Uniject is a trademark of BD.
†Sayana Press was approved in the European Union via procedure number UK/H/0960/002UK/H/0960/002. The UK was the Reference Member State. A Public Assessment Report is available at the Heads of Medicines Agency website and the Medicines and Healthcare Products Regulatory Agency web page.